Halofuginone hydrobromide

CAS No. 64924-67-0

Halofuginone hydrobromide ( Halofuginone HBr; Halofuginone-HBr )

Catalog No. M18953 CAS No. 64924-67-0

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 Get Quote
5MG 65 Get Quote
10MG 103 Get Quote
25MG 207 Get Quote
50MG 311 Get Quote
100MG 468 Get Quote
500MG 896 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Halofuginone hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
  • Description
    Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
  • Synonyms
    Halofuginone HBr; Halofuginone-HBr
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ProRS
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    64924-67-0
  • Formula Weight
    495.59
  • Molecular Formula
    C16H17BrClN3O3 · HB
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL 100.89 mM;
  • SMILES
    C1C[C@H]([C@@H](NC1)CC(=O)Cn1cnc2cc(c(cc2c1=O)Cl)Br)O.Br
  • Chemical Name
    (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
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