Halofuginone hydrobromide
CAS No. 64924-67-0
Halofuginone hydrobromide ( Halofuginone HBr; Halofuginone-HBr )
Catalog No. M18953 CAS No. 64924-67-0
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 40 | Get Quote |
|
5MG | 65 | Get Quote |
|
10MG | 103 | Get Quote |
|
25MG | 207 | Get Quote |
|
50MG | 311 | Get Quote |
|
100MG | 468 | Get Quote |
|
500MG | 896 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHalofuginone hydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionHalofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
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DescriptionHalofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
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SynonymsHalofuginone HBr; Halofuginone-HBr
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PathwayOthers
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TargetOther Targets
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RecptorProRS
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number64924-67-0
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Formula Weight495.59
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Molecular FormulaC16H17BrClN3O3 · HB
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Purity98%
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SolubilityDMSO : 50 mg/mL 100.89 mM;
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SMILESC1C[C@H]([C@@H](NC1)CC(=O)Cn1cnc2cc(c(cc2c1=O)Cl)Br)O.Br
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Chemical Name(2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
molnova catalog
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